How Does EXO|E Work?

EXO|E is designed to be highly compatible with skin tissues and involves three steps over an eleven-day regimen for skin rejuvenation and enhanced healing support. This system is water-based and manufactured in the USA.

Scientific research shows that many regenerative skincare technologies rely on extracellular vesicles (EVs) to deliver signaling molecules between cells.

These vesicles help coordinate processes such as inflammation control, angiogenesis (new blood vessel formation), and extracellular matrix remodeling, all of which play essential roles in skin repair and regeneration.

The three steps of the EXO|E program include the following:

D|TOX

This step prepares and hydrates your skin before an aesthetic treatment. It is applied twice daily for five days before a facial treatment, such as:

  • RF microneedling
  • Microneedling
  • Laser skin resurfacing
  • Other skin rejuvenation treatments that require downtime

Preparing the skin before treatment helps strengthen the skin barrier and optimize hydration, both of which are important factors in supporting wound healing and tissue repair.

EXO|E

After your treatment, your skin is nourished with advanced stem cell factors, including:

  • Extracellular nanoparticle technology (ENPT)
  • Liposomes
    Peptides
  • Growth factors
  • Anti-inflammatory ingredients

Exosomes are nano-sized vesicles typically measuring 30–150 nanometers, released naturally by cells and used for intercellular communication. They deliver proteins, growth factors, messenger RNA, and microRNA that help regulate processes involved in tissue repair and regeneration.

RE|REPAIR

To reinforce the healing factors introduced during treatment, RE|REPAIR continues the regenerative process with repeated application of biologic signaling molecules derived from plant stem cell sources. The serum is applied for five days following an aesthetic treatment to support ongoing recovery.

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EXO|E Charlotte Before & Afters

Left side is HaloPro with Exosomes D|Tox, EXO|E, and RE|PAIR = 11 day pre- and post-treatment kit. Right side is HaloPro without exosomes.

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What Can EXO|E Do for My Skin?

Recovery is an important part of any skin rejuvenation treatment. Procedures such as laser resurfacing or microneedling create controlled micro-injuries that stimulate collagen production as the skin repairs itself. During this healing phase, temporary redness, swelling, and sensitivity can occur.

EXO|E is designed to support the skin during this recovery period by delivering biologically active ingredients that help calm inflammation, maintain hydration, and support the skin’s natural repair processes. Plant-derived extracellular vesicles are also being studied for their antioxidant and anti-inflammatory properties and their role in cellular communication within the skin.

When incorporated into a treatment plan, EXO|E may help:

  • Reduce redness and inflammation after procedures
  • Support collagen and elastin production
  • Encourage healthy fibroblast activity
  • Maintain hydration and strengthen the skin barrier
  • Promote smoother healing and improved skin texture

Because the EXO|E system is formulated to be gentle and compatible with the skin barrier, it can be used across a wide range of skin types as part of a customized skin rejuvenation plan.

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Benefits of EXO|E The Ultimate Healing Treatment

Adding EXO|E to your treatment plan can significantly enhance results. The benefits include:

  • Faster healing – up to three times faster
  • Triggers natural skin regeneration, stimulating collagen, elastin, and HA production
  • Delivers 20 times the quantity of exosome cell signaling factors when measured against other exosome products
  • Calls on the skin’s natural regenerative capacity

Is EXO|E Right for Me? Experience Enhanced Outcomes and Faster Healing

When planning a treatment, we may recommend adding the EXO|E system to your treatment plan at Criswell & Criswell Plastic Surgery & Medspa. Our goal with every patient is to achieve the best possible outcome. Supporting the skin’s healing process with regenerative therapies can help optimize results and minimize downtime.

If you are planning any of the following skin rejuvenation treatments, speak with us about EXO|E:

  • Laser skin resurfacing
  • Microneedling
  • Microneedling with RF
  • Microdermabrasion
  • Chemical peels
  • Dermaplaning
  • Laser treatments for vascular lesions
  • Halo treatments
  • BBL treatments
  • Laser rosacea treatments
  • Laser acne scar treatments
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Criswell & Criswell Plastic Surgery & Medspa, Where Technology and Artistry Meet

Dr. Bryan Criswell and Dr. Kara Criswell are honored to have been named “Top Doctors” by Castle Connolly, as featured in Charlotte Magazine. Our board-certified plastic surgeons and talented aesthetic specialists create customized treatment plans designed to achieve natural-looking results.

With the addition of advanced technologies such as EXO|E, our patients may benefit from enhanced healing support and improved outcomes after aesthetic treatments.

You are invited to visit Criswell & Criswell Plastic Surgery & Medspa and experience a practice dedicated to patient safety, innovation, and personalized care. Our goal is to help you enjoy healthier, smoother, more radiant skin—so you can feel confident in your appearance and in the care you receive.

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Begin your transformation with confidence, care, and expertise.

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